Rational design of block copolymer self-assemblies in photodynamic therapy

• Maxime Demazeau,
• Laure Gibot,
• Anne-Françoise Mingotaud,
• Patricia Vicendo,
• Clément Roux and
• Barbara Lonetti

Beilstein J. Nanotechnol. 2020, 11, 180–212, doi:10.3762/bjnano.11.15

On the pathway of cellular uptake: new insight into the interaction between the cell membrane and very small nanoparticles

• Claudia Messerschmidt,
• Daniel Hofmann,
• Anja Kroeger,
• Katharina Landfester,
• Volker Mailänder and
• Ingo Lieberwirth

Beilstein J. Nanotechnol. 2016, 7, 1296–1311, doi:10.3762/bjnano.7.121

• : ATP depletion; calcium crystallization; cytotoxicity; endocytosis; HeLa cells; LDH; mesenchymal stem cells; morphology; necrosis; particle size; silica nanoparticles; TEM; Introduction Silicon dioxide nanoparticles (SiNPs) are used in a wide range of commercially available products to improve product

• NP concentration and size over 5 h of exposure in HeLa cells. Figure 7 displays the ATP level of HeLa cells exposed to NPs at 4 different concentrations and measured at time intervals of 60 min. At the lowest NP concentration (50 µg·mL−1, Figure 7A) SiNP-22 induces the highest ATP depletion effect

• regulated but functional ATP synthase. This effect was also shown by Dong et al. claiming that nanoparticles are potential effectors for the down regulation of ATP without inducing apoptosis but necrosis [46]. In the high concentration regime all examined NPs induced similar ATP depletion levels which